Sunday, September 18, 2011

Insulin Degrading Enzyme

What is it?:  Insulin Degrading Enzyme is a thiol zinc-metalloendopeptidase located on the cell surface and is responsible for insulin catabolism and degrading amyloid β-protein. Many of its functions and processes remain unknown.

Most Likely:
1) IDE can hinder the onset of Alzheimer's disease (1) (2) (3)

1) IDE can hinder the onset of type 2 diabetes (3) 

1) High levels of free fatty acids in the blood can inhibit production of insulin-degrading enzyme (4) ... (of course this seems obvious because in healthy people FFAs increase when blood glucose decreases, leading to less insulin needed by the body)

Studies that contributed:
1) Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)

2) Degradation of Alzheimer's B-Amyloid Protein by Human and Rat Brain Peptidases: Involvement of Insulin-Degrading Enzyme

3) Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

4) In Vitro Inhibition of Insulin-Degrading Enzyme by Long-Chain Fatty Acids and Their Coenzyme A Thioesters

Studies that didn't contribute (but still worth reading):
--Insulin-degrading enzyme

--Alzheimer's β-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

--Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues

--Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

--Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention

--Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

--Degradation of Soluble Amyloid b-Peptides 1-40, 1-42, and the Dutch Variant 1-40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brain

--Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

--Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

--Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

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