Insulin Degrading Enzyme

What is it?:  Insulin Degrading Enzyme is a thiol zinc-metalloendopeptidase located on the cell surface and is responsible for insulin catabolism and degrading amyloid β-protein. Many of its functions and processes remain unknown.



Most Likely:
1) IDE can hinder the onset of Alzheimer's disease (1) (2) (3)



Maybe:
1) IDE can hinder the onset of type 2 diabetes (3) 




Theory:
1) High levels of free fatty acids in the blood can inhibit production of insulin-degrading enzyme (4) ... (of course this seems obvious because in healthy people FFAs increase when blood glucose decreases, leading to less insulin needed by the body)






Studies that contributed:
1) Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)
http://www.jbc.org/content/277/16/13389.full

2) Degradation of Alzheimer's B-Amyloid Protein by Human and Rat Brain Peptidases: Involvement of Insulin-Degrading Enzyme

http://www.springerlink.com/content/u1nq74521582520m/

3) Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

http://www.sciencedirect.com/science/article/pii/S0197458005000199

4) In Vitro Inhibition of Insulin-Degrading Enzyme by Long-Chain Fatty Acids and Their Coenzyme A Thioesters

http://endo.endojournals.org/content/144/6/2404.full.pdf

Studies that didn't contribute (but still worth reading):
--Insulin-degrading enzyme
http://cat.inist.fr/?aModele=afficheN&cpsidt=3107042

--Alzheimer's β-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
http://www.sciencedirect.com/science/article/pii/0014579394003874

--Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues

http://endo.endojournals.org/content/132/2/604.short

--Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

http://hmg.oxfordjournals.org/content/9/14/2149.full

--Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor Signaling Cascade: Implications for Alzheimer's Disease Intervention

http://neuro.cjb.net/content/24/49/11120.full

--Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

http://www.nature.com/nature/journal/v443/n7113/abs/nature05143.html

--Degradation of Soluble Amyloid b-Peptides 1-40, 1-42, and the Dutch Variant 1-40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brain

http://www.springerlink.com/content/wj38321812010422/

--Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

http://neuro.cjb.net/content/20/5/1657.full

--Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

http://www.jbc.org/content/273/49/32730.full

--Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153065/